Don’t forget cameras where you want them and signaling where appropriate. I’m not imposing and specifics regarding signaling just try to make sure it all works. I’ll also add here tips for making routes truly finished.
1: Name ALL junctions even if the name is generic it makes a difference.
2: Fences make a big difference to industrial or commercial areas, try to use them.
3: Power lines, same reason as #2.
4: Name some buildings so they appear on the mini-map screen.
5: Static vehicles in appropriate places.
6: Set junctions to run straight through, to stop derailments.